Identification of and Human Serum Reactogenicity to Neutralizing Epitopes within the Central Unglycosylated Region of the Respiratory Syncytial Virus Attachment Protein ▿

摘要

We identified two overlapping neutralizing epitopes within residues 151 to 172 of the central unglycosylated region of the respiratory syncytial virus (RSV) attachment protein. In ∼40% of hospitalized and outpatient adults infected with RSV subtype A, these contiguous residues are the target of ≥4-fold increases in IgG response between acute- and convalescent-phase sera.